Treatment details
The Department of Hematology-oncology mainly treats hematologic neoplastic diseases and intractable blood diseases.
Hematologic oncology refers to so-called "blood cancers" such as leukemia, malignant lymphoma, and multiple myeloma, while intractable hematologic diseases refer to diseases requiring highly specialized treatment, such as aplastic anemia, idiopathic thrombocytopenic purpura, and hemophilia, which are designated as nationally designated diseases. The number of hematologists nationwide, including pediatric hematologists, is small, at approximately 2,700, and hospitals with full-time hematology specialists are also limited. Therefore, our Hematology-oncology 's medical service area is exceptionally wide, extending from central Kanagawa Prefecture and the Shonan district to eastern Shizuoka, among university hospitals in the Tokyo metropolitan area. We provide comprehensive services, from diagnosis to treatment, including hematopoietic stem cell transplantation, for patients with hematologic disorders in the region. Diagnosis and treatment of hematologic disorders require the support of multidisciplinary experts, including pathology, clinical laboratories, Division of Nursing, Division of Pharmacy, and clinical trial and transplant coordinators. One of our department's strengths, compared to other university hospitals, is the extensive staffing in each department.
Our greatest goal in Hematology-oncology is to provide high-quality medical care to local residents through the teamwork we have built up over many years.
Main target diseases
Hematologic neoplastic diseases
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Acute myeloid leukemia
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acute lymphoblastic leukemia
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Chronic myeloid leukemia
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Chronic lymphocytic leukemia
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Adult T-cell leukemia/lymphoma
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Myelodysplastic syndromes
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Malignant lymphoma (Hodgkin's lymphoma, non-Hodgkin's lymphoma)
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Multiple myeloma
Other blood disorders
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aplastic anemia
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Paroxysmal nocturnal hemoglobinuria
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hemolytic anemia
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Megaloblastic anemia
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polycythemia vera
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Essential thrombocythemia
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Idiopathic thrombocytopenic purpura
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Thrombotic thrombocytopenic purpura
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Hemophilia, etc.
Main medical achievements
acute leukemia
In recent years, advances in transplant medicine have made it possible for relatively elderly patients (around 70 years old) to receive this therapy. Additionally, several molecularly targeted drugs for acute leukemia have now emerged (BCL2 inhibitors, FLT3 inhibitors, dual antibodies, antibody-drug conjugates, etc.), and they are being used in relapsed and refractory cases, to prevent relapse after transplantation, and for elderly patients who previously had few treatment options. Our department also actively uses these drugs in an effort to improve overall treatment outcomes for acute leukemia.
Malignant lymphoma
We are a member of the Lymphoma Group of the Japan Clinical Oncology Group (JCOG), a research group led by the Ministry of Health, Labor, and Welfare. The incidence of malignant lymphoma has been increasing in recent years, with over 180 new cases diagnosed at our hospital alone last year. As a general rule, initial treatment is based on internationally supported "standard treatments," such as R-CHOP therapy and Pola+CHP therapy for non-Hodgkin's lymphoma, and A+AVD therapy for Hodgkin's lymphoma. If we determine that clinical trial participation would be beneficial to the patient based on factors such as histological type and progression, we may recommend that the patient participate in the trial. In particular, in recent years, promising new drugs have emerged for T-cell lymphoma, which previously had limited treatment options, and our department is also participating in clinical trials.
Multiple myeloma
The number of patients is increasing in recent years, reflecting the aging society. The prevalence in Japan is estimated at 2-3 cases per 100,000 people, and our hospital sees approximately 30 new patients annually. Treatment is based on the International Myeloma Working Group's diagnostic criteria, and is selected based on current evidence, taking into account age, general condition, disease stage, and chromosomal abnormalities. For patients who meet transplant criteria at the time of initial diagnosis, we actively perform autologous peripheral blood stem cell transplantation. In recent years, daratumumab has become available as an initial treatment in addition to bortezomib and lenalidomide, and treatment outcomes have improved thanks to treatment strategies aimed at achieving deep responses. Even for patients who have relapsed, we are treating them while maintaining their quality of life (QOL) through a combination of carfilzomib, ixazomib, pomalidomide, and elotuzumab. Furthermore, starting in 2023, we will be the only facility in Kanagawa to offer Abekuma CAR-T therapy. In addition, clinical trials of new drugs and chimeric antigen receptor gene-modified T cell (CAR-T) therapy are underway, and our department is participating in several of these trials.
About hematopoietic stem cell transplantation
When it is thought that a cure with standard drug therapy is difficult, hematopoietic stem cell transplantation may be indicated. Transplant cells are selected from among bone marrow/peripheral blood stem cells from a related donor with a matching histocompatibility test (HLA), bone marrow/peripheral blood stem cells from an HLA-matched bone marrow bank donor, or umbilical cord blood from an umbilical cord blood bank. Depending on the disease and the patient's age, a mini-transplant with reduced pre-transplant treatment may be selected.
Our department has an extensive track record of transplants, performing approximately 60 transplants annually, including approximately 50 allogeneic hematopoietic stem cell transplants and 10 autologous peripheral blood stem cell transplants. In recent years, the proportion of umbilical cord blood transplants has increased significantly. Treatment outcomes vary significantly depending on the patient's condition at the time of transplant (whether in remission or not, age, presence of complications, etc.) and the disease, making it difficult to uniformly evaluate outcomes. However, for diseases with poor prognoses, this is the only treatment aimed at achieving a cure, so we actively select the optimal time to perform it. Since 2006, the survival rate for allogeneic transplants has been approximately 50%, and many patients have successfully returned to society. Since 2015, we have been designated a regional core hospital for promoting hematopoietic stem cell transplantation, and since April 2020, we have been operating as a core transplant facility in the region.
Clinical trials
従来の標準治療を上回ると期待される、新しい治療方法や薬剤が開発された場合には、例え海外でエビデンスのある治療法であったとしても、国内での安全性と有効性の検証が必要となります。このためにおこなわれるのが、治験・臨床試験であり、日本で新薬が承認され、患者さんが投与を受けられるようになるために、必要不可欠なものです。血液腫瘍内科はその中心的存在として、白血病、悪性リンパ腫、多発性骨髄腫、胃髄異形成症候群などに対する数々の臨床試験をおこない、新薬の承認などに貢献してきました。またJCOG、JALSGなどの全国多施設共同研究にも積極的に参加しており、臨床研究を通して日本の血液疾患の治療成績向上に貢献することを、診療の大きな柱としています。これらの臨床試験はすべて、大学および付属病院の倫理審査委員会（IRB）の厳格な審査を経て承認を受け、施行されています。
治験・臨床試験の登録・実施状況は流動的です。ご質問がある場合には個別にお問い合わせ下さい。
Greetings
Doctor List
Department Chief: Yoshiaki Ogawa
Outpatient Chemotherapy Unit Director: Ken Omachi
Blood Bank Director: Seiko Toyoda
Chief of Ward 12B (sterile): Onizuka Masahito
Deputy Chief Physician of Ward 12B: Shinichiro Machida
Outpatient: 0463 (93) 1121 extension 6680
Professor Hiroshi Kawada
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine, Specialist and instructor of the Japanese Society of Hematology, Specialist of the Japanese Society of Anti-Aging Medicine |
| Specialized Areas | Molecular targeted therapy for hematologic tumors, drug therapy for hematopoietic diseases |
| Outpatient medical day | Wednesday and Friday |
Professor Yoshiaki Ogawa
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine / Specialist and instructor of the Japanese Society of Hematology |
| Specialized Areas | Drug therapy for hematopoietic diseases |
| Outpatient medical day | Monday, Thursday, Saturday |
Professor Makoto Onizuka
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine, specialist and instructor of the Japanese Society of Hematology, and certified doctor of the Japanese Society of Hematopoiesis and Immune Cell Therapy |
| Specialized Areas | Drug therapy for hematopoietic diseases, hematopoietic stem cell transplantation |
| Outpatient medical day | Wednesday and Friday |
Associate Professor Rikio Suzuki
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine, specialist and instructor of the Japanese Society of Hematology, and certified by the Japan Board of Certified Oncologists |
| Specialized Areas | Drug therapy for hematopoietic diseases, especially multiple myeloma |
| Outpatient medical day | Tuesday, Thursday, Friday |
Lecturer Ken Omachi
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine / Specialist and instructor of the Japanese Society of Hematology |
| Specialized Areas | Drug therapy for hematopoietic diseases |
| Outpatient medical day | Monday, Tuesday, Wednesday, Friday |
Lecturer: Shinichiro Machida
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine / Specialist and instructor of the Japanese Society of Hematology / Certified oncologist by the Japan Cancer Therapy Board / Certified doctor and council member of the Japanese Society of Hematopoietic and Immune Cell Therapy / Industrial physician diploma |
| Specialized Areas | Drug therapy for hematopoietic diseases, hematopoietic stem cell transplantation |
| Outpatient medical day | Monday, Thursday, Friday |
Lecturer: Masako Toyosaki
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine / Specialist and instructor of the Japanese Society of Hematology / Certified doctor and council member of the Japanese Society of Hematopoiesis and Immune Cell Therapy / Certified doctor and council member of the Japanese Society of Transfusion Medicine and Cellular Therapy / Certified doctor and council member of the Japanese Society of Autologous Blood Transfusion |
| Specialized Areas | Drug therapy for hematopoietic diseases, hematopoietic stem cell transplantation, transfusion medicine |
| Outpatient medical day | Tuesday and Wednesday |
Instructor: Daisuke Ogiya
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine / Specialist, instructor and council member of the Japanese Society of Hematology / Specialist and instructor of the Japanese Society of Clinical Oncology / Certified cancer treatment physician by the Japan Board of Certified Oncologists / Certified physician of the Japanese Society of Hematopoietic and Immune Cell Therapy |
| Specialized Areas | Drug therapy for hematopoietic diseases, immunotherapy for solid cancers, hematopoietic stem cell transplantation |
| Outpatient medical day | Mondays and Thursdays |
Lecturer: Hidetsugu Kawai
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine, Japanese Society of Hematology, and Japanese Society of Clinical Oncology |
| Specialized Areas | Drug therapy for hematopoietic diseases |
| Outpatient medical day | Monday and Friday |
Assistant Professor Ryujiro Hara
| Specialization | hematology |
|---|---|
| Specialist | Specialist and instructor of the Japanese Society of Internal Medicine, specialist and instructor of the Japanese Society of Hematology, and certified doctor of the Japanese Society of Hematopoiesis and Immune Cell Therapy |
| Specialized Areas | Drug therapy for hematopoietic diseases |
Assistant Professor Sawako Shiraiwa
| Specialization | hematology |
|---|---|
| Specialist | Certified physician of the Japanese Society of Internal Medicine, specialist of the Japanese Society of Hematology, and certified physician of the Japanese Society of Hematopoietic and Immune Cell Therapy |
| Specialized Areas | Drug therapy for hematopoietic diseases |
Miina Nasukawa, Clinical Assistant
| Specialization | hematology |
|---|---|
| Specialized Areas | Drug therapy for hematopoietic diseases |
Shinichi Tsunoda, Clinical Assistant
| Specialization | hematology |
|---|---|
| Specialist | Specialist of the Japanese Society of Internal Medicine |
| Specialized Areas | Drug therapy for hematopoietic diseases |
Shunsuke Tomita, Clinical Assistant
| Specialization | hematology |
|---|---|
| Specialized Areas | Drug therapy for hematopoietic diseases |