Greetings
Our department provides specialized medical care across the entire field of Department of Neurology, from acute illnesses such as stroke to neurodegenerative diseases, neuroimmunological diseases, dementia, and peripheral neuropathy. We admit approximately 800 inpatients annually and have one of the leading clinical records among university hospital Department of Neurology in Japan.
In addition to providing highly specialized treatment 24 hours a day for acute stroke, we also provide medical care for rare neurological diseases such as Parkinson's disease, multiple sclerosis, and myasthenia gravis, based on the latest knowledge from Japan and abroad, and propose optimal treatments aimed at improving function. In the field of dementia care, which has become a social problem in our aging society, as a core Dementia Treatment Department in Kanagawa Prefecture, we work closely with local medical institutions to build a comprehensive medical system from early diagnosis to treatment and support for daily living.
Our department has a diverse team of specialists, including stroke specialists, endovascular neurosurgery specialists, headache specialists, and neuroimmunology/genetics specialists, providing advanced and cutting-edge medical care for a wide range of neurological diseases. We also promote translational research that integrates basic research and clinical practice, and actively engage in the development of new treatments and clinical trials. This allows us to quickly deliver the most advanced medical care to our patients.
We will continue to strive to provide the best possible medical care for our patients, based on the latest evidence and technology.
Head of the Department of Neurology
Takato Abe
Treatment details
In our department, stroke accounts for approximately half of all cases, and we provide medical care across the entire field of Department of Neurology, from dynamic diseases such as acute cerebrovascular disorders to static diseases such as neurodegenerative diseases, neuroimmunological diseases, and peripheral neuropathy.
In particular, for cerebral infarction, we provide advanced acute care 24 hours a day in cooperation with the emergency medical center and Neurosurgery, including rt-PA intravenous therapy and endovascular treatment by endovascular specialists. In almost all cases, we perform MRI, MR angiography, carotid artery and cardiac echocardiography, and Holter ECG, and add transesophageal echocardiography as needed to determine the appropriate treatment plan. Furthermore, for cryptogenic cerebral infarction, we implant an implantable electrocardiogram recorder (Reveal LINQ) to actively search for the source of the embolus.
For Parkinson's disease, in addition to the latest drug therapies, we have introduced advanced treatments such as deep brain stimulation (DBS), enteral levodopa/carbidopa therapy (LCIG), and continuous subcutaneous infusion therapy (Vialev) for refractory cases. For neuroimmunological diseases such as multiple sclerosis and neuromyelitis optica, in addition to acute treatments such as steroid pulse therapy, specialists provide treatment based on the latest knowledge, including various disease-modifying drugs (DMDs) aimed at preventing relapses. We also offer advanced treatments for myasthenia gravis, including antibody therapies developed in recent years.
In dementia care, our hospital, as the only core Dementia Treatment Department in the prefecture, promotes collaboration with various facilities and local medical institutions throughout the prefecture. We utilize PET scans for the diagnosis of Alzheimer's disease and also offer novel antibody therapies for mild cognitive impairment (MCI).
For peripheral neuropathy, we actively implement immunoglobulin maintenance therapy, home self-injection (SCIG), and anti-FcRn antibody therapy for Guillain-Barré syndrome and CIDP. For migraines, we provide the latest treatments, such as CGRP-related antibody preparations, based on precise diagnoses by headache specialists. For status epilepticus, in severe cases, we perform electroencephalography (EEG) and other tests under ICU management to provide appropriate treatment.
Furthermore, for infectious diseases such as meningitis, we strive for early diagnosis and treatment by performing rapid imaging and cerebrospinal fluid examinations. In addition, we offer the latest treatments, including nucleic acid drugs, for rare diseases such as familial amyloid neuropathy (FAP).
Our department actively conducts clinical trials for various diseases in order to bring the latest treatment technologies back to patients. Furthermore, we have established a system capable of handling a wide range of intractable neurological diseases, including hereditary disorders, and we also provide genetic counseling by clinical genetic specialists.
Main target diseases
We treat a wide range of neurological conditions, including cerebral infarction and transient ischemic attacks (TIAs), cerebral hemorrhage, bacterial and viral meningitis, herpes encephalitis, prion diseases such as Creutzfeldt-Jakob disease, degenerative diseases such as Parkinson's disease and spinocerebellar degeneration, dementias such as Alzheimer's disease and Lewy body dementia, demyelinating diseases (neuroimmunological diseases) such as multiple sclerosis and acute disseminated encephalomyelitis (ADEM), functional disorders such as epilepsy, facial spasms, and headaches, peripheral neuropathy such as myopathy, ALS, Guillain-Barré syndrome, and CIDP, muscle diseases, rare diseases such as familial amyloid neuropathy, and general neurological conditions.
Main medical achievements
*Annual number of hospitalized patients at the affiliated hospital: 804 (From January 2024 to December 2024)
| disease | |
| Cerebrovascular disease | 353例 |
| Spinal cord and spinal disorders | 36例 |
| Epilepsy | 93例 |
| Encephalitis/Meningitis | 32例 |
| Neurodegenerative diseases | 12例 |
| Dementia | 5例 |
| Amyotrophic lateral sclerosis | 19例 |
| Multiple sclerosis/neuromyelitis optica-related disorders | 77例 |
| Peripheral nerve disease (including Guillain-Barré syndrome) | 33例 |
| Myasthenia gravis | 45例 |
| Muscle disease | 13例 |
| Parkinson's disease | 32例 |
| Metabolic diseases/toxicity | 3例 |
| Creutzfeldt-Jakob disease | 3例 |
| Others | 48例 |
Photo: An illustrative case of a patient with acute cerebral infarction. The patient presented with complete right-sided hemiplegia and was transported to our hospital 33 minutes after onset. A diffusion-weighted MRI (DWI) of the head on arrival revealed high signal intensity in the left basal ganglia, and magnetic resonance angiography (MRA) revealed occlusion of a middle cerebral artery. Intravenous thrombolysis was initiated 45 minutes after arrival, and endovascular treatment was performed 78 minutes later, achieving complete recanalization 138 minutes after onset. Atrial fibrillation was detected after admission, leading to a diagnosis of cardiogenic cerebral embolism due to atrial fibrillation. A novel oral anticoagulant was prescribed, and the patient was discharged home two weeks later, able to walk independently. As described above, this case highlights the effectiveness of acute treatment with thrombolytic therapy and endovascular treatment.
Doctor List
Department Head: Takato Abe
Deputy Chief Physician of Ward 10A: Atsushi Mizuma
Chief Physician of Ward 10B: Yoichi Onuki
Outpatient: 0463 (93) 1121 extension 6401
Professor Eiichiro Nagata
| Specialization | Headache, Neuromuscular disorders, Motor neuron diseases |
|---|---|
| Specialist | Certified Internal Medicine Doctor/ Certified by Neurology Specialist/ Stroke Specialist /Headache Specialist |
| Specialized Areas | Diagnosis and treatment of headaches, diagnosis and treatment of muscle and peripheral neuropathy, neuroimmune disorders, motor neuron diseases |
| Outpatient medical day | Mondays and Thursdays |
Professor Takato Abe
| Specialization | Cerebrovascular disease, Dementia |
|---|---|
| Specialist | General Internal Medicine Medicine Specialist, Certified by the Japanese Society of Internal Medicine, Neurology Specialist, Stroke Specialist, and Dementia Specialist |
| Specialized Areas | Thrombolytic therapy for acute cerebral infarction, antiplatelet therapy, prevention of recurrence, diagnosis and treatment of dementia |
| Outpatient medical day | Tuesday and Friday |
Associate Professor Yuko Onuki *
| Specialization | Neurological intractable diseases, Cerebrovascular disorders |
|---|---|
| Specialist | Certified Internal Medicine Doctor/Certified by Neurologist/Clinical Genetics Specialist |
| Specialized Areas | Genetic counseling for intractable neurological diseases, diagnosis and treatment of cerebrovascular disorders |
| Outpatient medical day | Monday |
Associate Professor Yoichi Onuki
| Specialization | Cerebrovascular disease |
|---|---|
| Specialist | Certified Internal Medicine Society Doctor/Neurology Specialist/Stroke Specialist/ Neuroendovascular Treatment Specialist |
| Specialized Areas | Endovascular treatment and diagnosis and treatment of cerebral infarction |
| Outpatient medical day | Wednesday and Thursday |
Associate Professor Atsushi Mizuma
| Specialization | Extrapyramidal disorders, neuroimmunological disorders |
|---|---|
| Specialist | General Internal MedicineGeneral Internal Medicine Specialist of the Japanese Society of Internal Medicine / Certified by Neurology Specialist / Stroke Specialist / Headache / Dementia Specialist / Neuroimmunology Specialist |
| Specialized Areas | Diagnosis and treatment of Parkinson's disease |
| Outpatient medical day | Monday, Wednesday, Thursday |
Lecturer: Mitsuhiko Yamano *
| Specialization | Epilepsy Internal Medicine Society Certified Doctor/Neurologist/Epilepsy Specialist |
|---|---|
| Specialist | Certified Internal Medicine Doctor/Certified by Neurology Specialist/ Epilepsy Specialist |
| Specialized Areas | Epilepsy diagnosis and treatment |
| Outpatient medical day | Friday and Saturday |
Assistant Professor Taira Nakayama
| Specialization | Cerebrovascular disease |
|---|---|
| Specialist | Certified Internal Medicine Doctor/Certified by Neurology Specialist/ Stroke Specialist |
| Specialized Areas | Diagnosis and treatment of cerebrovascular disorders |
| Outpatient medical day | Wednesday and Friday |
Assistant Professor Shizuka Nezu
| Specialization | General neurology, cerebrovascular disorders |
|---|---|
| Specialist | General Internal Medicine Certified by Neurology Specialist/ |
| Specialized Areas | Diagnosis and treatment of cerebrovascular disorders, neuroimmune diseases |
| Outpatient medical day | Saturday |
Assistant Professor Jun Togashi
| Specialization | General Neurology |
|---|---|
| Specialist | Certified by Internal Medicine Specialist |
| Outpatient medical day | Tuesday |
Assistant Professor Naoto Suzuki
| Specialization | General Neurology |
|---|---|
| Specialist | Certified by Internal Medicine Specialist |
| Outpatient medical day | Friday |
Assistant Professor Masanari Shirafuji
| Specialization | General Neurology |
|---|---|
| Outpatient medical day | Wednesday |
Assistant Professor Yuichi Ito
| Specialization | General Neurology |
|---|---|
| Outpatient medical day | Thursday |
Ryoko Imazeki (Part-time doctor) *
| Specialization | Cerebrovascular disease, dementia diagnosis and treatment |
|---|---|
| Specialist | General Internal Medicine / Certified byNeurology Specialist/Stroke Specialist / Headache Specialist/ Dementia Specialist |
| Specialized Areas | Diagnosis and treatment of dementia and headaches |
| Outpatient medical day | Monday (Afternoon) |
*These doctors' outpatient appointments cannot be booked directly from outside.
